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Research Insights

Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.

Virus-derived variation in diverse human genomes

Acquisition of genetic material from viruses by their hosts can generate interhost structural genome variation We developed computational tools enabling us to study virusderived structural variants SVs in populationscale whole genome sequencing WGS datasets and applied them to humans Although SVs had already been cataloged in these subjects

The landscape of antibody binding in SARS-CoV-2 infection

The search for potential antibodybased diagnostics vaccines and therapeutics for pandemic severe acute respiratory syndrome coronavirus SARSCoV has focused almost exclusively on the spike S and nucleocapsid N proteins Coronavirus membrane M ORFa and ORF proteins are humoral immunogens in other coronaviruses

The impact of age on genetic risk for common diseases

Inherited genetic variation contributes to individual risk for many complex diseases and is increasingly being used for predictive patient stratification Previous work has shown that genetic factors are not equally relevant to human traits across age and other contexts

Rare variants regulate expression of nearby individual genes in multiple tissues

The rapid decrease in sequencing cost has enabled genetic studies to discover rare variants associated with complex diseases and traits Once this association is identified the next step is to understand the genetic mechanism of rare variants on how the variants influence diseases Similar to the hypothesis of common variants

Bioinformatics prediction of differential miRNAs in non-small cell lung cancer

Nonsmall cell lung cancer NSCLC accounts for of all lung cancers The drug resistance of NSCLC has clinically increased This study aimed to screen miRNAs associated with NSCLC using bioinformatics analysis We hope that the screened miRNA can provide a research direction for the subsequent treatment

A patient-oriented research approach to assessing patients’ and primary care physicians’ opinions on trauma-informed care

To gather patients and primary care physicians PCP opinions on traumainformed Care TIC and to investigate the acceptability of recommendations developed by patient family and physician advisors

Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium

Biopharmaceutical products BPs are widely used to treat autoimmune diseases but immunogenicity limits their efficacy for an important proportion of patients Our knowledge of patientrelated factors influencing the occurrence of antidrug antibodies ADAs is still limited

DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines

DNA supercoiling is essential for all living cells because it controls all processes involving DNA In bacteria global DNA supercoiling results from the opposing activities of topoisomerase I which relaxes DNA and DNA gyrase which compacts DNA These enzymes are widely conserved sharing amino acid identity between the closely related

BADAN-conjugated β-lactamases as biosensors for β-lactam antibiotic detection

Lactam antibiotic detection has significant implications in food safety control environmental monitoring and pharmacokinetics study Here we report the development of two BADANconjugated lactamases ECb and ECbNQ as sensitive biosensors for lactam antibiotic detection

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

The ataxia telangiectasia and Radrelated ATR protein kinase is a key regulator of the cellular response to DNA damage Due to increased amount of replication stress cancer cells heavily rely on ATR to complete DNA replication and cell cycle progression Thus ATR inhibition is an emerging target in cancer therapy

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