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Research Insights

Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.

Functional human genes typically exhibit epigenetic conservation

Recent DepMap CRISPRCas single gene disruptions have identified genes more essential to proliferation in tissue culture It would be valuable to translate these finding with measurements more practical for human tissues Here we show that DepMap essential genes and other literature curated functional

Roadmap for the use of Base Editors to Decipher Drug Mechanism of Action

CRISPR base editors are powerful tools for largescale mutagenesis studies This kind of approach can elucidate the mechanism of action of compounds a key process in drug discovery Here we explore the utility of base editors in an early drug discovery context focusing on Gprotein

Multifunctional RNA-binding Proteins Influence mRNA Abundance and Translational Efficiency of Distinct Sets of Target Genes

RNAbinding proteins RBPs can regulate more than a single aspect of RNA metabolism We searched for such previously undiscovered multifunctionality within a set of RBPs by defining the predictive value of RBP abundance for the transcription and translation levels of known RBP target genes

RNA Editing Regulates lnc RNA Splicing in Human Early Embryo Development

RNA editing is a co or posttranscriptional modification through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after transcription Previous studies found that RNA editing may be critically involved in cancer and aging However the function of RNA editing in human early

Interpretable Machine Learning for High-dimensional Trajectories of Aging Health

We have built a computational model for individual aging trajectories of health and survival which contains physical functional and biological variables and is conditioned on demographic lifestyle and medical background information We combine techniques of modern machine learning with an interpretable interaction network where health

Modeling the Onset of Symptoms of COVID-19 Effects of SARS-CoV-2 Variant

Identifying order of symptom onset of infectious diseases might aid in differentiating symptomatic infections earlier in a population thereby enabling nonpharmaceutical interventions and reducing disease spread Previously we developed a mathematical model predicting the order of symptoms based on data from the initial outbreak

Immunogenicity and Safety of Primary Fractional-dose Yellow Fever Vaccine in Autoimmune Rheumatic Diseases

Brazil faced a yellow feverYF outbreak in and vaccination was considered for autoimmune rheumatic disease patientsARD with low immune suppression due to YF high mortality Yellow feverYF is an infectious disease caused by a Flavivirus Flaviviridae family Severe cases may evolve to bleeding disorders

Microsimulation Based Quantitative Analysis of COVID-19 Management Strategies

Pandemic management requires reliable and efficient dynamical simulation to predict and control disease spreading The COVID SARSCoV pandemic is mitigated by several nonpharmaceutical interventions but it is hard to predict which of these are the most effective for a given population

A Simple Assay to Quantify Mycobacterial Lipid Antigen-specific T Cell Receptors in Human Tissues and Blood

T cell receptors TCRs encode the history of antigenic challenge within an individual and have the potential to serve as molecular markers of infection In addition to peptide antigens bound to highly polymorphic MHC molecules T cells have also evolved to recognize bacterial lipids when

Vaccine Equity: A fundamental imperative in the fight against COVID-19

On March WHO declared the outbreak of severe acute respiratory syndrome coronavirus SARSCoV a global pandemic Now almost years on COVID continues to cause widespread morbidity mortality and disruption both directly and indirectly on a global scale The speed at which multiple effective vaccines were developed is a remarkable

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